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demeclocycline hydrochloride

demeclocycline hydrochloride

CAS: 64-73-3

Molecular Formula: C21H21ClN2O8.ClH

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demeclocycline hydrochloride - Names and Identifiers

Name demeclocycline hydrochloride
Synonyms DEMECLOCYCLINE
declomycinhydrochloride
DEMECLOCYCLINE HYDROCHLORIDE
demeclocycline hydrochloride
demethylchlortetracyclinehydrochloride
chlorodemethyltetracyclin hydrochloride
demethylchlorotetracyclinehydrochloride
7-CHLORO-6-DEMETHYLTETRACYCLINE HYDROCHLORIDE
6,10,12,12a-pentahydroxy-1,11-dioxo-ydro-monohydrochloride
7-chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide hydrochloride
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride (8CI)
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
CAS 64-73-3
EINECS 200-592-2
InChI InChI=1/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6?,7?,14?,15-,21?;/m0./s1
InChIKey GVSJQNRGSCOSNJ-KBHRXELFSA-N

demeclocycline hydrochloride - Physico-chemical Properties

Molecular FormulaC21H21ClN2O8.ClH
Molar Mass501.32
Melting Point>245°C (dec.)
Water SolubilitySoluble in water.
Solubility Soluble in water (20 mg/ml), DMSO, and methanol.
Appearancepowder
ColorLight Yellow to Yellow
Merck13,2905
BRN5705221
pKapKa 3.3 (Uncertain)
Storage ConditionSealed in dry,Store in freezer, under -20°C
MDLMFCD00082371
Physical and Chemical PropertiesMelting point> 245°C (dec.)
storage conditions − 20°C

solubility H2O: 20 mg/mL, clear, very deep green yellow

form powder

Merck 13,2905
UseAn antibiotic related to tetracycline and produced by streptomyces aureofaciens.

demeclocycline hydrochloride - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes43 - May cause sensitization by skin contact
Safety Description36/37 - Wear suitable protective clothing and gloves.
WGK Germany2
RTECSQI7700000
FLUKA BRAND F CODES8-10-21
HS Code29413020
ToxicityLD50 orally in rats: 2372 mg/kg (Goldenthal)

demeclocycline hydrochloride - Reference Information

EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Overview norchlortetracycline, mainly used in the production of minocycline and tigecycline. Its antibacterial activity is strong, the antibacterial spectrum is similar to chlortetracycline, its effect is stronger than tetracycline and oxytetracycline, and it is more stable than chlortetracycline. It is an important raw material product in the field of biological medicine, however, in the current production process of norchlortetracycline, due to the long-term technical blockade of foreign countries to our country, the production of norchlortetracycline products in our country is relatively lagging behind and lacks high efficiency and reliability, and low-cost production process of norchlortetracycline products.
attribute norchlortetracycline, alias dicyclin, desmethylchlortetracycline, etc, it is a tetracycline antibiotic produced by the fermentation of Streptomyces Aureus. Its antibacterial spectrum is similar to that of chlortetracycline, and its antibacterial effect is stronger than tetracycline and more stable than chlortetracycline.
extract 35 liters of fermentation broth containing 6.0g/L of norchlortetracycline, adjust the temperature to 5-10 ℃, add 0.05wt% sodium sulfite 35g, adjust the temperature to 10 ℃, use oxalic acid to adjust the pH = 1.5±0.2, stir for 20 minutes, use Nanjing Jiuwu ceramic membrane filtration, ceramic Membrane flux 30 L/h; Filtrate 70 L;
Filtrate 122 resin, flow rate 2BV/h, after the completion of the use of pH = 6.8-7.0 of the drinking water top wash 0.5 hours, the decolorization of 72 liters;
organic nanofiltration membrane module of GE company of USA, whose decolorizing liquid has a molecular weight cut-off of 150 daltons, at a pressure of 1.5mpa and a temperature of 5-10 ℃, was used to obtain 4 liters of concentrated liquid;
under the condition of stirring the concentrated solution, the temperature was adjusted to 5-8 ° C., and the pH was adjusted to 6.5±0.2 with 0.1M ammonia water to obtain a precipitated suspension, which was further stirred for 30 minutes and allowed to stand for 30 minutes, the crude product of demethylchlortetracycline was obtained by solid-liquid separation;
The crude product of demethylchlortetracycline was refined by urea double salt method to obtain the finished product of demethylchlortetracycline, and dried to obtain 152g of demethylchlortetracycline hydrochloride. The yield was 72.38%; The product was submitted to meet EP and USP standards.
biological activity Demeclocycline HCl is a tetracycline antibiotic that inhibits bacterial protein synthesis and is used to treat bacterial infections.
Last Update：2024-04-09 21:01:54
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Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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